Organoids closely resemble organs in morphology and physiology, providing unique opportunities for disease research under in vitro condition
Heart organoids can be used to study the pathogenesis of various heart diseases. By simulating pathological states like myocardial infarction and heart failure, scientists can gain insights into these diseases' development and progression, aiding in identifying new therapeutic targets and providing theoretical foundations for drug development.
Compared to traditional animal experiments, heart organoids can better reflect human heart responses, enhancing the accuracy and efficiency of drug screening. This method can reduce research and development costs and decrease the reliance on animal testing.
Using a patient's own cells to culture heart organoids can construct personalized disease models. For example, generating heart organoids from a patient's iPSCs can simulate specific heart pathologies, helping doctors develop precise treatment plans and evaluate therapeutic effects.
Scientists may use heart organoid technology to repair or replace damaged heart tissue, offering new treatment methods. This approach could address the shortage of heart transplant donors and improve the success rate of transplant surgeries.
Heart organoids can be used to assess the impact of environmental toxins and chemicals on the heart, providing crucial toxicology data. This is significant for environmental protection and public health monitoring.
Cardiac organoids formed through small molecule induction of iPSCs can autonomously contract within six days. The produced cardiac organoids 100% express the following cardiac-specific markers:
Cardiac organoids derived from human iPSCs perfectly replicate the developmental process and structural functions of the human heart. Compared to Drosophila and animal models, they offer advantages of being faster, more accurate, and highly efficient. Our products have been utilized by university users (UPenn) to test whether newly discovered mechanosensitive genes in Drosophila have similar expression and functions in humans. Preliminary experimental results indicate that the candidate genes discovered in Drosophila exhibit homologous spatiotemporal expression during human heart development, providing an excellent experimental model for the development of cardiac disease drugs.
The Na⁺/K⁺ currents of cardiomyocytes form the basis of cardiac electrophysiological activity, with the main characteristics including:
Our cardiomyocytes exhibit the typical characteristics of Na⁺/K⁺ currents, ensuring the normal electrophysiological function of cardiomyocytes and the effective pumping function of the heart.
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